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Microsoft poskytl FBI uživatelské šifrovací klíče svého nástroje BitLocker, nutné pro odemčení dat uložených na discích třech počítačů zabavených v rámci federálního vyšetřování. Tento krok je prvním známým případem, kdy Microsoft poskytl klíče BitLockeru orgánům činným v trestním řízení. BitLocker je nástroj pro šifrování celého disku, který je ve Windows defaultně zapnutý. Tato technologie by správně měla bránit komukoli kromě majitele zařízení v přístupu k datům, ve výchozím nastavení se však šifrovací klíče nahrávají přímo do cloudů Microsoftu.

Nový korejský prášek okamžitě zastaví nebezpečné krvácení během jediné sekundy • Směs přírodních polymerů vytvoří v ráně pevný gel a zničí bakterie • Materiál vydrží stabilní dva roky bez chlazení a urychluje hojení tkáně

TRINITY BANK od 1. 4. 2026 přidá hned tři nové dokumenty pro poskytování bankovních služeb. Mění se základní obchodní podmínky, produktové podmínky pro účty a podmínky pro internetové bankovnovnictví.

Drone, satellite, and other data combined to monitor unwanted vessels

The UK Home Office is spending up to £100 million on intelligence tech in part to tackle the so-called "small boats" issue of refugees and irregular immigrants coming across the English Channel.…

Vyšla Opera One R3, která iteruje řadu aspektů prohlížeče. • AI může vycházet z kontextu aktuální stránky a je rychlejší. • Skupiny stránek můžete pojmenovat a vybrat pro ně barvu.

The Russian nation-state hacking group known as Sandworm has been attributed to what has been described as the "largest cyber attack" targeting Poland's power system in the last week of December 2025. The attack was unsuccessful, the country's energy minister, Milosz Motyka, said last week. "The command of the cyberspace forces has diagnosed in the last days of the year the strongest attack on

The Russian nation-state hacking group known as Sandworm has been attributed to what has been described as the "largest cyber attack" targeting Poland's power system in the last week of December 2025. The attack was unsuccessful, the country's energy minister, Milosz Motyka, said last week. "The command of the cyberspace forces has diagnosed in the last days of the year the strongest attack on Ravie Lakshmananhttp://www.blogger.com/profile/[email protected]

AI agents are accelerating how work gets done. They schedule meetings, access data, trigger workflows, write code, and take action in real time, pushing productivity beyond human speed across the enterprise. Then comes the moment every security team eventually hits: “Wait… who approved this?” Unlike users or applications, AI agents are often deployed quickly, shared broadly,

AI agents are accelerating how work gets done. They schedule meetings, access data, trigger workflows, write code, and take action in real time, pushing productivity beyond human speed across the enterprise. Then comes the moment every security team eventually hits: “Wait… who approved this?” Unlike users or applications, AI agents are often deployed quickly, shared broadly, [email protected]

The U.S. Cybersecurity and Infrastructure Security Agency (CISA) on Friday added a critical security flaw affecting Broadcom VMware vCenter Server that was patched in June 2024 to its Known Exploited Vulnerabilities (KEV) catalog, citing evidence of active exploitation in the wild. The vulnerability in question is CVE-2024-37079 (CVSS score: 9.8), which refers to a heap overflow in the

The U.S. Cybersecurity and Infrastructure Security Agency (CISA) on Friday added a critical security flaw affecting Broadcom VMware vCenter Server that was patched in June 2024 to its Known Exploited Vulnerabilities (KEV) catalog, citing evidence of active exploitation in the wild. The vulnerability in question is CVE-2024-37079 (CVSS score: 9.8), which refers to a heap overflow in the Ravie Lakshmananhttp://www.blogger.com/profile/[email protected]

Vdechování oxidu dusného přináší rychlou úlevu pacientům s rezistentní depresí • Jednorázový účinek po týdnu vyprchá. Opakované podání tento efekt prodlužuje • Plyn blokuje receptory v mozku a funguje podobně jako ketamin

In 2026, lower-end PCs may be more difficult to come by, and for those that are available, price tags may rise.

This is fallout from Intel’s plans to pivot its manufacturing capacity from chips for PCs to Xeon processors to support intensive AI workloads. The company has admitted that it had miscalculated demand for its data center products, and will now go all-in on AI-ready hardware.

This strategic turn indicates how voracious companies are for infrastructure that can power intensive AI workloads, to the point that even tech giants like Intel aren’t prepared for the demand.

“Intel’s move to prioritize data center capacity is in response to a supply-demand mismatch, or rather, faulty forecasting from their hyperscaler customers who rapidly shifted to the higher core-count solution late last year,” noted Scott Bickley, advisory fellow at Info-Tech Research Group.

Accelerating Xeon

In an earnings call this week, Intel CFO David Zinsner acknowledged capacity constraints in Q3 and Q4 as demand for its Xeon products soared. Intel Xeon 6 server processors (codenamed Granite Rapids and Sierra Forest) were designed for data centers, cloud, AI, and high performance computing (HPC), and are widely used by Nvidia.

At the same time, industry-wide demand for key components like dynamic random-access memory (DRAM), NAND, and substrates is ballooning due to intense demand for AI-ready infrastructure, said Zisner.

Just six months ago, he noted, unit sales were not expected to increase. “Every hyperscaler customer we talked to was signaling that,” he said. However, Intel experienced a rapid increase in orders for Xeon processors over the third and fourth quarters, and, after talking with hyperscalers, Zinsner said he got the impression that this will be “a story we’d feel for several years.”

“To the extent we have excess, we’re pushing all of that into the data center space to meet that customer demand,” he said. “We have important OEM customers, both data center and client, and that must be our priority to get the limited supply we have to those customers.”

Roadmaps altered

The company has made “decisive changes” to simplify its server road map, according to CEO Lip-Bu Tan. It will focus more closely on Diamond Rapids (Xeon gen 7) and accelerate delivery of Coral Rapids (Xeon 8), which will feature simultaneous multithreading (SMT), where one core can process two or more threads at once.

However, the company will not abandon its client business, Zinsner emphasized. “We can’t completely vacate the client market,” he said, “so we’re trying to support both as best we can, and obviously work our way out of this supply issue.”

That said, within the client segment, the company will particularly focus on mid- and high-end products (Core-series high-performance processors), as opposed to low end products (for less advanced PCs).

Intel is leaning heavily into AI PCs, having showcased its Core Ultra Series 3 (codenamed Panther Lake) at CES earlier this month, and said it is on track to release Nova Lake (its next mainstream client CPU following Core Ultra Series 3) this year.

“We now have a client road map that combines best-in-class performance with cost-optimized solutions,” said Tan.

The outlook for lower-end PCs

What does this mean for lower-end PCs? Zinsner acknowledged that “client CPU inventory is lean,” even amid excitement for Series 3. Further, “rising component pricing is a dynamic we continue to watch closely, especially relative to the client market.”

The Intel 18A node manufacturing process for Panther Lake is challenged with lower than expected yields, which “throttles output vs market demand,” said Info-Tech’s Bickley. “Coupled with a focus on their mid-high end markets, this makes the lower-end entry-level laptops and PCs materially more difficult to source.”

Anshel Sag, principal analyst at Moor Insights & Strategy, agreed there may be fewer low-end SKUs in 2026, and the ramp for products like Wildcat Lake, an entry-level Core Series 3 CPU, might be later in the year, or could slip into next year as 18A capacity increases.

Processors from AMD and Qualcomm could help address some of the shortfalls, especially in the mid-range, Sag forecasted; at the low end, more price-conscious users may push into Android via Google’s Project Aluminium and through partners like Mediatek, which currently rule that market.

As lower-cost inventory buffers are depleted, buyers can expect price increases ranging from 15% to 20% in 2026, with some brands “hiking prices higher to salvage margins,” said Bickley. He projects PC manufacturers will lean into the AI PC trend, focusing less on lower-cost models and shifting production to machines that utilize higher-end CPU chips and memory components.

However, he noted, “CPUs are not being cannibalized by GPUs. Instead, they have become ‘chokepoints’ in AI infrastructure.” For instance, CPUs such as Granite Rapids are essential in GPU clusters, and for handling agentic AI workloads and orchestrating distributed inference.

How pricing might increase for enterprises

Ultimately, rapid demand for higher-end offerings resulted in foundry shortages of Intel 10/7 nodes, Bickley noted, which represent the bulk of the company’s production volume. He pointed out that it can take up to three quarters for new server wafers to move through the fab process, so Intel will be “under the gun” until at least Q2 2026, when it projects an increase in chip production.

Meanwhile, manufacturing capacity for Xeon is currently sold out for 2026, with varying lead times by distributor, while custom silicon programs are seeing lead times of 6 to 8 months, with some orders rolling into 2027, Bickley said.

In the data center, memory is the key bottleneck, with expected price increases of more than 65% year over year in 2026 and up to 25% for NAND Flash, he noted. Some specific products have already seen price inflation of over 1,000% since 2025, and new greenfield capacity for memory is not expected until 2027 or 2028.

Moor’s Sag was a little more optimistic, forecasting that, on the client side, “memory prices will probably stabilize this year until more capacity comes online in 2027.”

How enterprises can prepare

Supplier diversification is the best solution for enterprises right now, Sag noted. While it might make things more complex, it also allows data center operators to better absorb price shocks because they can rebalance against suppliers who have either planned better or have more resilient supply chains.

Bickley urged enterprises to also establish hybrid AI strategies that split workloads between the cloud and client device PCs, to defer reliance on oversubscribed compute. Where possible, invest in memory optimization tools and extend refresh cycles for existing hardware to avoid the 2026 price peak, as well as auditing supply chains to gain earlier visibility to component risks.

Further, “shift to multi-year commitments and away from spot buying,” he advised. “This requires longer-term planning and strategic supply agreements to guarantee allocation in a capacity-limited environment.”

Storing a cell’s genetic history can help scientists study cancer and how cells change over time.

In the 1980s, UCLA cellular biologist Leonard Rome noticed odd, barrel-shaped structures present in almost all cells. The hollow particles were filled with RNA and a handful of proteins. Naming them vaults, Rome has tried to understand their purpose ever since.

Though vaults remain enigmatic, their unique structure recently inspired a separate team. Led by Fei Chen at the Broad Institute of MIT and Harvard, the scientists engineered vaults to collect and store messenger RNA (mRNA) molecules for up to a week. The mRNA vaults they created act like ledgers that detail which genes are turned on or off over time.

In several tests, opening the vaults and reading the mRNA stored within shed light on gene activity that helps cancer cells evade treatment. The method, called TimeVault, also tracked the intricate symphony of gene expression that pushes stem cells to mature into different cell types.

The work is “superpowerful” and “very innovative,” Jiahui Wu at the University of Massachusetts, who was not involved in the study, told Science.

Jay Shendure, an expert in cellular recorders at the University of Washington, agrees. It took “some creativity and some guts” to transform vaults into time capsules, he told Nature.

A Cell’s Life

Each cell is a metropolis humming with activity. Proteins zoom across its interior to coordinate behaviors. Structures called organelles churn out new proteins or recycle old ones to keep cells healthy. Scores of signaling molecules relay information from the environment to the nucleus, where our DNA resides. All this information causes the cell to turn certain genes on or off, allowing it to adapt to a changing biological world.

Scientists have long tried to spy on these intricate cellular processes. Using a common tool, they can tag molecules with glow-in-the-dark protein markers and track them under the microscope. This provides real-time data but only for a handful of proteins over a relatively short time.

Another approach takes snapshots of which genes are active in single cells or groups of cells, usually at the beginning and end of an experiment. Here, scientists extract mRNA, a molecule that carries gene expression information, to paint an overall picture of a cell’s current state. Comparing genetic activity between one point of time and another provides insight into the cell’s history. But unlike a video, these snapshots can’t capture nuanced changes over time.

More recently, a slew of cell recorders based on the gene editor CRISPR have galvanized the field. These tools encode information about cellular events into DNA, essentially forming a “video” of events inside cells that can be retrieved later by sequencing the DNA. Genomic recordings are relatively stable and have been used to map cell lineages—a bit like reconstructing a family tree—and record specific cell signals, such as those responding to viral infection, inflammation, nutrients, or other stimuli. But because they directly write into DNA, the process takes time and could trigger off-target effects.

Enter the Vault

Instead of tinkering with the genetic blueprint, mRNA may be a safer choice. These molecules carry protein-making instructions from DNA and have a relatively short lifespan. In other words, they reflect all the active genes in a cell at any moment, making them perfect candidates for a time capsule. But without protection, they’re rapidly destroyed—often within hours.

The team first tried to stabilize mRNA molecules by tethering them to a bacterial protein. It didn’t work. But after serendipitously stumbling across a YouTube channel by the Vault Guy, also known as Leonard Rome, they had an out-of-the-box idea. Cellular vaults are known to encapsulate some of life’s molecules. Could they also keep mRNA safe?

Vaults are made of 78 copies of a long protein. These proteins are woven into a barrel-shaped shell with a mostly hollow interior. To make their vault-based time capsule, the team first made a protective protein cap for the mRNA. This stabilized the molecules. The cap also links up with a slightly tweaked vault protein, engineered to tether captured mRNA molecules into a vault.

The team built in a switch too. TimeVault starts recording when cells are dosed with a chemical and stops as soon as the chemical washes out. Viewing the recording of gene activity is simple. The team retrieves the vaults and sequences all of the mRNA inside. TimeVault reliably stores the molecules for at least a week in multiple types of cells in petri dishes.

In a test, the technology faithfully captured mRNA in cells exposed to heat or low oxygen. Both are common ways to stress cells and force them change their gene expression. The mRNA profiles captured by TimeVault matched genetic responses measured using other methods, suggesting the recorder functions with high fidelity.

Another test showcased the time capsule’s power to observe complex diseases, such as lung cancer. Some tumor cells thwart medications and survive treatment. These cells don’t contain mutations that lead to drug resistance, suggesting they’re able to escape in other ways.

Using TimeVault, the team logged the cells’ activity before treatment began and discovered a ledger of genes, some previously not linked to cancer, that protect tumors from common therapies. By comparing gene expression from before and after treatment, they homed in on several overactive genes. Shutting these down boosted a cancer drug’s ability to kill more tumor cells, with one chemical cocktail lowering resistance to the cancer treatment.

The team is just beginning to explore TimeVault’s potential. One idea is to capture mRNA for longer periods of time from a single cell to record its unique genetic history. They’re also eager to re-engineer the technology so it works in mice, allowing scientists to capture an atlas of gene expression in living animals.

“By linking past and present cellular states, TimeVault provides a powerful tool for decoding how cells respond to stress, make fate decisions, and resist therapy,” wrote the team.

The post Scientists Turn Mysterious Cell ‘Vaults’ Into a Diary of Genetic Activity Through Time appeared first on SingularityHub.

Spotify prostřednictvím svého FOSS fondu rozdělilo 70 000 eur mezi tři open source projekty: FFmpeg obdržel 30 000 eur, Mock Service Worker (MSW) obdržel 15 000 eur a Xiph.Org Foundation obdržela 25 000 eur.

But ex-CISA boss and new RSAC CEO Jen Easterly will be there

updated  The US Cybersecurity and Infrastructure Security Agency won't attend the annual RSA Conference in March, an agency spokesperson confirmed to The Register. Sessions involving speakers from the FBI and National Security Agency (NSA) have also disappeared from the agenda.…

The ShinyHunters extortion gang claims it is behind a wave of ongoing voice phishing attacks targeting single sign-on (SSO) accounts at Okta, Microsoft, and Google, enabling threat actors to breach corporate SaaS platforms and steal company data for extortion. [...]

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