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Pokud bychom měli vypíchnout jednu věc, která se AMD s Ryzen 9 9950X3D2 povedla (a nikdo to nerozporuje), pak je to vyvolání emocí. Zvládl toho však podstatně více…

France Titres, the government agency in France for issuing and managing administrative documents has disclosed a data breach after a threat actor claimed the attack and stealing citizen data. [...]

NCSC boss says China's whole-of-state cyber machine has become Britain's peer competitor in cyberspace

State-sponsored cyberattacks from Chinese intelligence and military agencies display "an eye-watering level of sophistication," UK National Cyber Security Centre CEO Richard Horne is expected to say in a less-than-cheery opening speech to kick off its annual conference.…

Lawmakers decry CISA cuts: 'We are shooting ourselves in the foot'

If a cyberattack leads to a death, that's murder. A former FBI cyber division chief urged the US Justice Department to consider felony homicide charges against ransomware actors when attacks on hospitals lead to patient deaths.…

A new tool that tethers healthy mitochondria to ailing cells has shown promise in mice with inherited blindness.

Our cells produce energy in biological power plants called mitochondria. These energy-makers have minds of their own. They operate using a unique set of DNA and can travel outside cells. Like astronauts, they often escape in fatty bubbles, land on other cells, explore them, and sometimes literally fuse with native mitochondria in their new homes.

This makes mitochondrial diseases hard to treat. Few gene editing tools can reach them and fix genetic typos. Even without mutations, mitochondria falter with age, contributing to diabetes, Alzheimer’s disease, heart failure, and other medical scourges.

But an experimental fix is gaining traction. Researchers are shuttling healthy mitochondria into cells—essentially transplanting them—to restore energy production and reboot metabolism.

There’s a major roadblock, however. Getting healthy mitochondria to the right cells is challenging. Scientists at the Institute of Molecular and Clinical Ophthalmology Basel have now developed a system that tethers donated mitochondria to their targets.

Called MitoCatch, the scientists engineered matching proteins and attached them to donor mitochondria and recipient cells. Like hook-and-eye fasteners, the binders pull the two partners into close contact. From there—by mechanisms that are still mysterious—the new mitochondria ride in on fatty bubbles, disembark inside the cell, and get to work.

In the study, the researchers delivered mitochondria to multiple cell types, and an injection of mitochondria saved vulnerable retinal cells in mice with inherited blindness.

“As a therapy, mitochondria transplantation has been hindered by the lack of tools to target healthy mitochondria directly to disease-affected cells,” wrote Samantha Krysa and Jonathan Brestoff at Washington University School of Medicine, who were not involved in the study.

MitoCatch overcomes this barrier.

Domesticated Bacteria

Roughly two billion years ago, an ancestral cell ate a bacterium. But rather than digesting it, the cell formed an unlikely alliance with its erstwhile prey. The bacterium converted oxygen into energy for the host, and received protection and nutrients in return. Over time, the bacterium gave up its independence and became a critical part of our cells: mitochondria.

Unlike other cell structures called organelles, mitochondria carry 37 unique genes that encode the core components of their energy-making machinery. Their stripped-down genome leaves little margin for error and is especially vulnerable to mutation. It’s also shielded by a double membrane, making it difficult to reach using conventional biotech tools.

But mitochondria have a superpower: They can leave host cells. Research from the last two decades shows that many cells export some mitochondria into the cellular void. The practice could be a way to rid themselves of damaged mitochondria or to deliver healthy ones to struggling neighbors, like an intercellular care package.

This quirk led to the idea of mitochondrial transplantation. Here, healthy mitochondria are injected into tissue or the bloodstream to treat damaged cells. Early results are encouraging. Transplant extends the healthy lifespan of mice with mitochondrial defects, limits injury after stroke or heart attack, accelerates wound healing in people, and hints at benefits for obesity.

Because nearly every human cell depends on mitochondria for energy—and falters when they break—transplantation could unlock treatments for a broad range of diseases hard to treat today. That is, if healthy replacements can reach their destination.

“Being able to deliver mitochondria efficiently to the right cell types has been a key hurdle for this therapeutic strategy,” wrote Krysa and Brestoff.

Catch Me if You Can

MitoCatch relies on a cellular “handshake.” All cell surfaces are densely studded with proteins, some universal, others unique to specific cell types. These proteins interact with surrounding molecules to drive biological processes. During infection, for example, antibodies latch onto proteins on bacteria to trigger an immune attack. CAR T cell therapy outfits T cells with protein “binders” so they can better recognize and eliminate cancer cells, senescent cells, or cells involved in autoimmune disorders. In each case, success hinges on matched protein pairs snapping together like hook-and-eye fasteners.

The new system works on the same principle and has three designs. MitoCatch-M helps donor mitochondria recognize markers unique to different types of recipient cells. MitoCatch-C flips the approach, modifying recipient cells with binders that better capture mitochondria. And a third version uses a “bispecific” tether that simultaneously grips mitochondria and target cells. Once in close proximity, mitochondria are packaged in fatty bubbles that drift into the cell.

Then comes a brief moment of terror.

Many of these bubbles are routed to the cell’s waste processing organelle, where their cargo is completely destroyed. The mitochondria must escape before it’s too late.

In cultured brain, retinal, heart, skin, and immune cells, the tailored mitochondria largely avoided death. How they managed this up for debate, and the team is trying to work it out now. But once inside, the donor mitochondria fused with the cell’s native mitochondrial network.

This “suggests that MitoCatch can be used to enhance the efficacy of mitochondria transplantation substantially,” wrote Krysa and Brestoff.

Of course, cells in a dish aren’t the same as those in bodies. In another test, the team injected the engineered mitochondria into the eyes of mice with a hereditary condition where a single mitochondrial genetic defect destroys cells in the retina, resulting in gradual vision loss.

Over 10 days, the healthy mitochondria revamped treated cells’ metabolisms, reduced damage, and boosted survival and response to light. Whether this translates to better vision remains to be seen, but the treatment didn’t trigger an immune response, a promising sign it might be safe. To be clear, the transplanted mitochondria didn’t correct the underlying mutation. Instead, they supplied enough working versions of the gene to bring energy production back to life.

It’s “a proof-of-principle that mitochondria transplantation can be used to correct mutations encoded in the mitochondrial genome that cause a severe form of vision loss,” wrote Krysa and Brestoff.

MitoCatch isn’t ready for prime time. It requires extensive genetic engineering, making the system difficult to translate for routine treatment. It’s also still unclear how long transplanted mitochondria last in their new hosts and whether they have a lasting benefit.

These early results highlight the ways scientists can boost the therapy’s potential. With more work, we may have a new way to tackle previously untreatable mitochondrial disorders.

The post Scientists Revive Failing Cells With Mitochondria Transplants appeared first on SingularityHub.

LinkedIn is testing a new AI feature, Crosscheck, which allows users to compare several popular AI models directly on the platform. Users enter prompts into Crosscheck and receive two different responses generated by competing AI models from companies such as OpenAI, Anthropic, and Google.

After the user selects the best response, the model behind each answer is revealed. LinkedIn product manager Hari Srinivasan describes the service as a kind of blind taste test for AI models, according to Engadget.

Crosscheck works only with text, but has no limits on the number of questions. At the same time, LinkedIn shares anonymized user data with the AI companies to provide insights into how the models perform across different professional groups.

The feature is initially available to LinkedIn Premium subscribers in the US, with plans to expand to more countries and free users soon.

A previously undocumented data-wiping malware dubbed Lotus was used last year in targeted attacks against energy and utilities organizations in Venezuela. [...]

Threat actors associated with The Gentlemen ransomware‑as‑a‑service (RaaS) operation have been observed attempting to deploy a known proxy malware called SystemBC. According to new research published by Check Point, the command-and-control (C2 or C&C) server linked to SystemBC has led to the discovery of a botnet of more than 1,570 victims. "SystemBC establishes SOCKS5 network tunnels withinRavie Lakshmananhttp://www.blogger.com/profile/[email protected]

Update na Android 16 mohou čekat majitelé mnoha zařízení • V tomto přehledu se dozvíte, zda dorazí i do vašeho telefonu • Článek pravidelně aktualizujeme, výrobce řadíme podle abecedy

Adobe Summit serves as a platform for Adobe to introduce new services, capabilities, and enhancements to its portfolio of creative and marketing software and services. The 2026 edition kicks off live in Las Vegas on April 20, with a virtual event running alongside it.

The company has long been a name to watch as a developer of creativity and design software. This year will be a pivotal one for Adobe, with the recent announcement that its CEO is stepping down after 18 years at the helm, and the rise of AI tools challenging both creators and the software vendors that serve them. Expect announcements setting out Adobe’s response to those challenges — and watch for signs that the company may be changing direction or losing ground to AI offerings from companies such as Microsoft, OpenAI, or Google.

Adobe is also one of the bigger players in the enterprise digital marketing solutions, and Adobe Summit will also provide insights into changes to Adobe Marketing Cloud and Adobe Experience Platform.

Follow this page (and this one) for the latest news and insights from Adobe 2026, and check out recent related coverage below.

Adobe news and analysis Adobe bets on AI agents to stay at the center of marketing workflows

April 24, 2026: Facing pressure from rival design software vendors and general-purpose AI assistants, Adobe is rolling out agentic systems to coordinate and execute creative work across workflows and apps.

Adobe builds an ‘agentic content supply chain’ for the AI era

April 21, 2026: Adobe is adding new capabilities to GenStudio and Firefly to automate content creation and provide agentic assistants to keep up with branding as it evolves in the age of AI. The additions include a ‘Workflow Optimization Agent’ in Adobe Workfront, its workflow management platform.

Adobe bets on agentic AI to rewrite SaaS for customer experience

April 20, 2026: Adobe is shifting its approach to what it calls ‘Customer Experience Orchestration (CXO).’ Announced today at Adobe Summit, the new Adobe CX Enterprise suite is a pivot to a future defined by agents rather than by software alone, where SaaS companies claim an advantage based on their deep domain expertise and troves of first- and third-party data.

The top priority for Adobe’s next CEO? Prepping for the ‘age of agents’

April 9, 2026: Adobe CEO Shantanu Narayen announced plans to step down last month after 18 years leading software vendor. For whomever is tapped next for the top job — the CEO search is expected to take several months — the biggest priority will almost certainly be reshaping Adobe’s products and strategy for the next wave of agentic AI, analysts said.

Adobe Acrobat Standard review: A polished PDF editor with clear limits

March 16, 2026: Adobe Acrobat Standard is Adobe’s entry paid-tier PDF editor, sitting between the free Acrobat Reader and the more fully featured Acrobat Pro. It’s meant for people who need more than viewing, signing, and basic annotations, but not Adobe’s full set of advanced document tools. It handles routine PDF work well, but advanced features still require a move up to Pro.

Adobe CEO steps down after 18 years

March 13, 2026: It’s all change at the top for Adobe as CEO Shantanu Narayen is stepping down after 18 years. He will relinquish the role as soon as a successor has been found, although he will continue to serve as chairman. The creative software company’s new boss will have to face the challenge of AI.

Adobe makes Agent Orchestrator and AI agents generally available

September 10, 2025: Adobe has launched AEP Agent Orchestrator and six AI agents for building, delivering, and optimizing customer experiences and marketing campaigns. Agent Composer, coming soon, will aid with customizing and configuring agents.

Adobe Commerce and Magento users: Patch critical SessionReaper flaw now

September 10, 2025: Adobe issued an emergency patch for one of the most severe vulnerabilities ever discovered in the Magento Open Source ecommerce platform and Adobe Commerce, its enterprise counterpart. The flaw allows unauthenticated attackers to hijack user accounts and, in some cases, execute arbitrary code on servers. Security experts warn of exploits soon.

Adobe is developing an agent to integrate Adobe Express with Microsoft 365

March 20, 2025: Adobe is working with Microsoft to develop an AI agent that can generate graphics and design content from within the Microsoft 365 interface. The Adobe Express Agent, still under development, will allow users to create and embed graphics directly within productivity applications such as Word and PowerPoint.

Adobe makes agentic AI push with Agent Orchestrator, purpose-built agents

March 18, 2025: Adobe unveiled Agent Orchestrator, a new capability for Adobe Experience Platform (AEP) to supervise AI agents, whether from Adobe or third-party ecosystems. It also introduced 10 new agents built on the capability at Adobe Summit 2025.

CISA gives federal agencies 4 days to patch

America's lead cyber-defense agency has warned that three Cisco Catalyst SD-WAN Manager bugs are under attack, and given federal agencies just four days to patch the security holes.…

Notebooky do 25 tisíc se řadí mezi ty nejoblíbenější • Při výběru už nemusíte dělat mnoho kompromisů • Jsou zde hlavně kancelářské notebooky, objevují se ale i herní stroje

Byl vydán Mozilla Firefox 150.0. Přehled novinek v poznámkách k vydání a poznámkách k vydání pro vývojáře. Řešeny jsou rovněž bezpečnostní chyby. Nový Firefox 150 bude brzy k dispozici také na Flathubu a Snapcraftu.

Data from browsers, cryptocurrency wallets, 200+ extensions hoovered up

A ClickFix campaign targeting macOS users delivers an AppleScript-based infostealer that collects credentials and live session cookies from 14 browsers, 16 cryptocurrency wallets, and more than 200 extensions.…

Cybersecurity researchers have identified 22 new vulnerabilities in popular models of serial-to-IP converters from Lantronix and Silex that could be exploited to hijack susceptible devices and tamper with data exchanged by them. The vulnerabilities have been collectively codenamed BRIDGE:BREAK by Forescout Research Vedere Labs, which identified nearly 20,000 Serial-to-Ethernet converters exposedRavie Lakshmananhttp://www.blogger.com/profile/[email protected]

Jen máloco rozvířilo v poslední době pocity hráčů tak jako oznámení DLSS 5. Nvidia posunula „vylepšování“ her na jinou úroveň a hráči se ptají, zdali po zásahu DLSS 5 vůbec jde o stejné hry.

Byl představen (reddit, 𝕏) webový prohlížeč Brave Origin. Jedná se webový prohlížeč Brave bez VPN, krypto peněženky a odměn, tj. bez funkcí, ze kterých je vývoj Brave financován. Stojí jednorázově 59,99 dolarů. Verze pro Linux je zdarma.

Cestu lidské posádky k Měsíci po více než půl století od programu Apollo si můžete připomínat každý den na ploše svého počítače nebo mobilu. NASA zveřejnila snímky z mise Artemis II rozdělené do několika galerií podle fáze letu. Dokonce připravila i přímo tapety pro mobily. Posádka měla na palubě ...