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Microsoft cheat sheets: Dive into Windows, Office, and Copilot
Need to get up to speed on the latest features in Excel? Wrestling with an old version of Word? Looking to get more out of Windows 11? Computerworld’s cheat sheets are easy-to-use guides to help you navigate Microsoft’s core productivity software.
Here’s a one-stop resource where you can find in-depth stories on several generations of Word, Excel, PowerPoint, and Outlook for Windows, focusing on what’s new in each major release. We’ve also got guides for Windows itself, as well as Microsoft Teams, OneDrive (both in Windows and on the web), OneNote, Loop, Whiteboard, Forms, Visio, Planner, and Power Automate.
Microsoft’s subscription-based office suite, called Microsoft 365, is continually updated with new features, so we periodically refresh the cheat sheets for the “365” versions of Word, Excel, PowerPoint, Outlook, and other apps in the suite. But some companies and individuals will likely stay on older versions of the non-subscription software (Office 2021, for example) for some time to come, so we’ve got cheat sheets for several generations of those products as well.
The biggest change in both Microsoft 365 and Windows in recent years is the widespread integration of Microsoft’s generative AI assistant, Copilot. We’ve got tips to help you get the most out of that tool too, with more on the way.
Windows, Office, and Copilot tutorials and tips- Microsoft Copilot
- Windows 10 and 11
- Microsoft 365 apps
- Office 2021 and 2024
- Office 2016 and 2019
- Office 2013
- Office 2010
- Windows 8
The free version of Microsoft’s generative AI chatbot is available in a standalone app, in the Edge browser, and on the web. Here’s how to make the most of it.
New: 11 cool things Copilot can do in ExcelAs Microsoft ramps up Copilot’s capabilities in Excel, the AI tool is becoming genuinely useful for spreadsheet work.
New: Copilot Chat: Your hub for document creation and analysisAnyone with a Microsoft 365 account can use new AI agents in Copilot Chat to jump-start Word, Excel, and PowerPoint documents — and some users can enlist a special agent to analyze their M365 files. Here’s how.
Microsoft Copilot can boost your writing in Word, Outlook, and OneNote — here’s howCopilot integration in Microsoft 365 apps makes it a snap to generate first drafts, revise text, and get instant summaries for long docs or email threads. Here’s how to use Copilot for writing assistance in Word, Outlook, and OneNote.
How to curb hallucinations in Copilot (and other genAI tools)Generative AI chatbots like Microsoft Copilot make stuff up all the time. Here’s how to rein in those lying tendencies and make better use of the tools.
Windows 10 and 11 Windows 11 cheat sheetTo a great extent, Windows 11 looks and works like Windows 10, but there are several minor differences that take some getting used to. We cover all the important changes here, including Copilot integration and new three- and four-finger touchscreen gestures.
Windows 10 cheat sheetWindows 10 is no longer receiving updates, but if you’re still using this reliable workhorse, here’s a guide to the key features. Don’t miss our list of handy gestures and shortcuts for Windows 10.
Microsoft OneDrive cheat sheet: Using OneDrive in WindowsIf you have Windows 10 or 11, you have OneDrive. Here’s how to back up, sync and share files in OneDrive and OneDrive for Business on the Windows desktop.
More tips for Windows 10 and 11- How to curb hallucinations in Copilot (and other genAI tools)
- Microsoft Copilot tips: 9 ways to use Copilot right
- Updated: 8 ways to be more productive in Windows 11
- 15 ways to speed up Windows 11
- Updated: How to protect your privacy in Windows 11
- How to repair Windows 10 or 11 in 4 steps
- How to handle Windows 10 and 11 updates
- How to protect Windows 10 and 11 PCs from ransomware
- How to share a Windows 10 or 11 PC
- 12 classic but essential (and free!) utilities for Windows 10 and 11
- 18 ways to speed up Windows 10
- How to protect your privacy in Windows 10
- 30+ free and cheap apps for Windows 10
Learn to use the best features introduced in Word for Microsoft 365 in Windows over the past several years. This story covers features introduced in Word 2016, 2019, 2021, and 2024, plus several more exclusive to Microsoft 365 subscribers — and to those with a Microsoft 365 Copilot license.
Related:
- Handy Word keyboard shortcuts for Windows and Mac
- Microsoft Copilot can boost your writing in Word, Outlook, and OneNote — here’s how
- Updated: 10 quick productivity tips for Microsoft 365 mobile apps
- Microsoft Word for Android (and iOS) cheat sheet
Learn about the most important features introduced in Excel over the past several years, with an emphasis on those exclusive to Microsoft 365 subscribers — and to users with a Microsoft 365 Copilot license.
Related:
- Handy Excel keyboard shortcuts for Windows and Mac
- New: 11 cool things Copilot can do in Excel
- Updated: 10 quick productivity tips for Microsoft 365 mobile apps
- How to use PivotTables and PivotCharts in Excel
- How to use slicers in Excel
- Excel basics: Get started with tables
- Excel basics: Get started with charts and sparklines
- How to use Excel formulas and functions
- How (and why) to use conditional formatting in Excel
- How to use Excel macros to save time and automate your work
- 10 spiffy new ways to show data with Excel
- Excel: Your entry into the world of data analytics
- How to use Excel as a data visualization tool
- 8 simple ways to clean data with Excel
Learn to use the best features introduced in PowerPoint for Microsoft 365 in Windows over the past several years. This story covers the major features introduced in PowerPoint 2016, 2019, 2021, and 2024, plus several more exclusive to Microsoft 365 subscribers — and to those with a Microsoft 365 Copilot license.
Related:
- Handy PowerPoint keyboard shortcuts for Windows and Mac
- Updated: 10 quick productivity tips for Microsoft 365 mobile apps
Discover all the major features introduced in Outlook 2016, 2019, 2021, and 2024, plus more exclusively for Microsoft 365 subscribers — including a simplified Ribbon that shows only the most commonly used commands.
Related:
- Handy Outlook keyboard shortcuts for Windows and Mac
- Microsoft Copilot can boost your writing in Word, Outlook, and OneNote — here’s how
- Updated: 10 quick productivity tips for Microsoft 365 mobile apps
- Use Outlook’s new calendar board view to organize your work
- 8 Outlook add-ins to enhance collaboration
- How to filter Outlook emails on all your devices
- Updated: How to check your co-workers’ schedules in Outlook and Teams
- How to work across time zones in Outlook
Microsoft’s new Loop app provides shared workspaces where teams can collaborate. Our cheat sheet shows you how to use the Loop app.
How to use Loop components in Microsoft 365 appsWhat makes Loop particularly useful is the ability to collaborate on content snippets called Loop components across multiple Microsoft 365 apps. Here’s how to use Loop components in Outlook, Teams, and other M365 apps.
Updated: Microsoft Teams cheat sheet: How to get startedMicrosoft’s answer to Slack and Zoom, Teams provides group messaging, voice and video calls, and useful integrations with other Microsoft 365 apps. Here’s how to get set up in Teams and find your way around.
Related:
- 28 power user tips for Microsoft Teams
- 14 best practices for Microsoft Teams video meetings
- The 10 best new Microsoft Teams meeting features
- Updated: How to check your co-workers’ schedules in Outlook and Teams
- How to have Teams meetings with people outside your organization
- 18 Microsoft Teams apps for content collaboration and management
Part of Microsoft’s Office suite and built into Windows 10 and 11, OneNote is a robust note-taking app that is also available as a free standalone product. Here’s how to get up and running with OneNote.
Related:
- Microsoft Copilot can boost your writing in Word, Outlook, and OneNote — here’s how
- Updated: 10 quick productivity tips for Microsoft 365 mobile apps
OneDrive for Web lets you save, access, share, and manage your files in the cloud using your favorite browser. Learn how to use the web interface — and Copilot AI with it — for a big productivity boost.
Updated: Microsoft Forms cheat sheet: How to get startedOnline forms help you conduct research, collect feedback, test knowledge, and more. Here’s how to use Microsoft Forms to create surveys, feedback forms, quizzes, and other interactive forms.
Microsoft Visio cheat sheet: How to get startedVisio in Microsoft 365 is an excellent tool for creating custom diagrams to illustrate concepts that are difficult to explain through text. Here’s how to use it.
13 tips to get the most out of Microsoft WhiteboardFor Microsoft 365 users, it’s worth adding Microsoft Whiteboard to your collaboration playbook. Here’s how your team can make the most of this digital whiteboard tool.
Updated: Microsoft Planner cheat sheetPlanner gives Microsoft 365 users a built-in task-management tool that small teams can use to track plans, tasks, and progress. Here’s our guide to using Planner on the web and within Microsoft Teams.
Microsoft Power Automate: How to get startedWith Power Automate, you can create automated workflows for a wide range of business tasks across multiple apps and services — no coding required. Here’s how to get up and running, along with tips for creating reliable automations.
SharePoint Online cheat sheetLearn how to find your way around SharePoint Online (the Office 365 version of SharePoint), create sites, share and manage documents, work with calendars, integrate with Outlook and more. Then go beyond the basics in 5 tips for working with SharePoint Online.
More tips for Microsoft 365/Office- 10 highly useful add-ins for Microsoft Office
- 5 collaboration tools that enhance Microsoft Office
- Updated: 5 steps to repair Microsoft Office
Microsoft 365 may get all the attention, but the classic Microsoft Office suite also gets useful additions in every release. Here’s how to use the best new features in Office 2021 and Office 2024.
Office 2016 and 2019 Word 2016 and 2019 cheat sheetLearn how to use Word’s live collaborative editing features, Tell Me and Smart Lookup, and the new Translator pane in Word 2019. Also included is a list of handy keyboard shortcuts for Word 2016 and 2019. If you just want to know where to find various commands on the Ribbon, download our Word 2016 and 2019 Ribbon quick reference.
Excel 2016 and 2019 cheat sheetNow updated for Excel 2019, our guide covers several useful chart types introduced in Excel 2016 and Excel 2019 for Windows, as well as how to use several impressive new data analysis tools. We’ve also got a list of handy keyboard shortcuts in Excel, as well as the Excel 2016 and 2019 Ribbon quick reference.
PowerPoint 2016 and 2019 cheat sheetLike Word and Excel, PowerPoint 2016 and PowerPoint 2019 for Windows offer Tell Me, Smart Lookup, live collaborative editing and a slew of new chart types. We cover all that plus some handy features introduced in PowerPoint 2019 — not to mention our list of keyboard shortcuts for PowerPoint and the PowerPoint 2016 and 2019 Ribbon quick reference.
Outlook 2016 and 2019 cheat sheetOutlook 2016 for Windows has been enhanced with Smart Lookup, Tell Me, and features to help you find files you want to attach and keep a tidy inbox. And don’t miss our list of keyboard shortcuts for Outlook 2016 and 2019 and the Outlook 2016 and 2019 Ribbon quick reference.
Office 2013 Word 2013 cheat sheetAmong the major features introduced in Word 2013 are a Start screen, a Design tab, Read Mode, and OneDrive sync. Our guide covers how to use them all and provides handy keyboard shortcuts for Word 2013. There’s also a Word 2013 Ribbon quick reference.
SharePoint 2013 cheat sheetLearn the basics of navigating and using a SharePoint site, where to go to find some of the customization options, and 5 advanced SharePoint 2013 tips.
Office 2010 Word 2010 cheat sheetLearn how to use Word 2010’s Navigation pane, image editing tools, text effects and other new features. Also see the list of handy keyboard shortcuts for Word 2010 and our Word 2010 Ribbon quick reference charts.
Excel 2010 cheat sheetExcel 2010 introduces Sparklines, Slicers, and other enhancements to PivotTables and PivotCharts. Find out how to use those, along with keyboard shortcuts for Excel 2010 and our quick reference for finding your favorite commands on the Excel 2010 Ribbon.
PowerPoint 2010 cheat sheetLearn how to use PowerPoint 2010’s multimedia editing tools, sharing options and other handy features. As usual, we’ve got keyboard shortcuts for PowerPoint 2010 and a guide to finding old PowerPoint 2003 commands on the PowerPoint 2010 Ribbon.
Outlook 2010 cheat sheetThe Ribbon was only half-present in Outlook 2007, but in Outlook 2010 it’s ubiquitous. Other notable changes include Conversation View to group email messages, Schedule View for scheduling meetings, and an enhanced search function. We show you how to use them all, provide some handy keyboard shortcuts for Outlook 2010 and detail where old Outlook 2003 commands are located in Outlook 2010.
SharePoint 2010 cheat sheetUnlike earlier versions of SharePoint, SharePoint 2010 is based on the Ribbon interface. Here’s how to find your way around and get started with a SharePoint site.
Windows 8 Windows 8 cheat sheetNot many people are still using this nightmare of an operating system, which radically overhauled the classic Windows interface in an attempt to make it more like a mobile OS. Just in case, here’s help finding your way around. (But seriously, it’s way past time to upgrade to a newer OS.)
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A Revolutionary Cancer Treatment Could Transform Autoimmune Disease
Researchers are testing CAR T cell therapy as a way to reset the immune system in lupus, Graves’ disease, and other conditions where the body’s defenses go rogue.
This story was originally published by Knowable Magazine.
At age 49, Jan Janisch-Hanzlik’s multiple sclerosis was destroying her freedom to live the life she wanted. She gave up her active nursing job for a desk role. Frequent falls made her afraid to carry her grandchildren. She had to move to a bigger house to make room for the wheelchair she feared she might end up needing full-time.
Even the best available medication wasn’t improving Janisch-Hanzlik’s symptoms, and she worried they’d only get worse. So when she learned about a trial of CAR T cell therapy at the University of Nebraska Medical Center in Omaha, close to the city of Blair where she lives, she phoned the clinic every other month until they were ready to enroll her as the first patient.
Originally designed to target and wipe out cancer by reprogramming the patient’s immune cells, CAR T is now being offered to patients in hundreds of clinical trials for autoimmune conditions like multiple sclerosis, lupus, Graves’ disease, vasculitis, and many others. The hope is that CAR T can duplicate the success it has demonstrated in a range of blood cancers by hunting down and eliminating cells that target the self in autoimmune diseases. This would essentially reset the body’s defenses to a state like the one that existed before the disease took hold.
But along with CAR T’s promise come risks, questions and challenges. There’s uncertainty about how well it will work for autoimmunity and how long any benefits might last, as well as what long-term side effects might arise. Janisch-Hanzlik knew this when she sat down to receive the experimental treatment on June 9, 2025; she felt a mix of hope and fear knowing that she would be spending the next week being monitored for side effects including dangerous inflammation.
In addition to her clinical expertise and desire to pioneer a new treatment, Janisch-Hanzlik’s two young grandchildren helped inspire her pursuit of a treatment with known risks and uncertain benefits. Because multiple sclerosis has a genetic component, Janisch-Hanzlik knew that they have an elevated chance of going through the same struggle she has. “I would want to be able to say I did everything that I possibly could to prevent them, or anyone else, from having something like this,” she says.
From Cancer to AutoimmunityThe first CAR T cancer treatment was approved by the Food and Drug Administration in 2017 for an aggressive form of leukemia. Since then, the powerful and intensive treatment has resulted in long-term remission for many cancer patients.
The basic premise of CAR T is to activate the power of key immune cells called T cells. T cells normally recognize other cells that have been infected by a virus or bacterium, or are otherwise abnormal, and either destroy them or recruit other parts of the immune system to do so.
In CAR T for cancer, scientists engineer those T cells to specifically hunt and destroy malignant cells. The technology got its start when cancer researchers figured out how to take out a patient’s own T cells, insert DNA instructions for a “chimeric antigen receptor,” or CAR, and put them back into the person’s circulation. The CAR, which sits on the T cell’s surface and latches on to a specific molecular partner on the surface of cancerous cells, activates the T cell to attack.
Today, CAR T cells are most commonly programmed to attack B cells, another key immune player. B cells are normally responsible for making antibodies, but in certain blood cancers, they proliferate out of control. By giving T cells a CAR that recognizes one of a couple of molecules unique to the B cell surface, the cells are reprogrammed to find and eliminate those cancerous cells.
B cells also are the central problem in many autoimmune conditions: They mistakenly make antibodies against normal tissues instead of against invading pathogens. So as CAR T began to succeed against B cell cancers, it didn’t take long for doctors to reason that CAR T therapy might also be able to wipe out bad B cells in people with autoimmunity.
A German team pioneered autoimmune CAR T in a woman with lupus, reporting positive results in 2021. Since then, that team and others have worked to translate the oncology success of CAR T to tackle a broad spectrum of autoimmune diseases.
“I think it’s a game changer,” says Amanda Piquet, an autoimmune neurologist at the University of Colorado Anschutz in Aurora. Piquet is evaluating CAR T therapy for a rare and poorly understood autoimmune condition called stiff person syndrome, with symptoms including muscle stiffness and painful spasms. There is no FDA-approved treatment. When she heard about a company called Kyverna that was testing CAR T cell therapy in the syndrome, she thought it was “a perfect opportunity.”
The study she led, which reported preliminary results in December 2025, tested a single dose of CAR T in 26 people. Before the treatment, many participants struggled with a slow, mechanical gait, and 12 used assistive devices such as walkers and canes. Most patients were able to walk faster by 16 weeks post-treatment, and eight no longer needed their assistive devices for short distances. In April, the company reported that all 26 patients, as of their last follow-up appointment four to 12 months out from the therapy, were no longer using any other immunotherapies.
Risks and UncertaintiesDespite such striking results, reprogramming the immune system is no simple matter. In early treatment of cancer patients, CAR T cells produced life-threatening side effects, as outlined in a 2026 article in the Annual Review of Medicine. As CAR T cells attack their targets, the associated inflammation can cause symptoms like high fevers and low blood pressure. If that inflammation reaches the brain, it can cause additional problems such as confusion and drowsiness.
Fortunately, physicians now have a decade’s worth of experience recognizing and treating these problems. “They’re certainly reversible and don’t cause long-term damage most of the time,” says Emily Littlejohn, a rheumatologist at the Cleveland Clinic.
Physicians and patients also must contend with decreased immunity as both a side effect of the treatment and its desired outcome. In CAR T treatment, doctors typically use powerful chemotherapy drugs to temporarily reduce the body’s immune cell population to make room for the new, engineered cells, leaving patients temporarily immunosuppressed. And if the treatment works, it will decimate B cell populations. Patients can be vulnerable to infections for up to a year after treatment, says Littlejohn.
These effects are manageable with preventive antibiotics, antivirals, and vaccines. Patients also retain antibodies that their B cells made before the treatment, which provide residual protection for a few months. And for reasons that are not yet fully understood, CAR T seems to leave older B cells, which provide immune memory of past infections, intact in some cases. One study found that autoimmune patients treated with CAR T still made antibodies for diseases they’d been previously vaccinated against, like chicken pox and measles. These are signs that the treatment did not completely return the immune system to its factory settings.
When evaluating CAR T risk, it’s important to consider that many existing treatments for autoimmune disease also suppress the immune system for as long as a person takes them, experts note.
But there are other possible CAR T risks for autoimmune patients. In February, FDA officials published a paper endorsing CAR T’s potential in autoimmunity but warning of “unpredictable long-term toxicity.” CAR T treatment for cancer, the authors noted, has been linked to diverse long-term issues such as Parkinson’s disease. There have also been cases where the bioengineered cells themselves turned malignant, causing new, T cell-based cancers.
Causing a secondary cancer may be an acceptable risk when treating a life-threatening cancer, but probably not for autoimmunity, says Matt Lunning, medical director for gene and cellular therapy at Nebraska Medicine in Omaha. How to balance the risk between the impacts of an autoimmune disease, which can range widely in severity, and the difficult-to-quantify risk of future side effects or cancers remains a major open question.
Researchers are already working on second- and third-generation versions of CAR T that they expect to be safer for both cancer and autoimmunity. For example, James Howard, a neuromuscular neurologist at the University of North Carolina at Chapel Hill, is testing a technology from a company called Cartesian Therapeutics that encodes the CAR using molecules of mRNA, the short-lived genetic messenger used in Covid-19 vaccines, instead of long-lasting DNA. The CAR T cells should wipe out B cells for only as long as the mRNA persists, then lose their B cell-targeting abilities. With no chance for genetically modified T cells to hang around long-term, there should be no cancer risk.
Another plus of Cartesian’s approach: Physicians infuse these T cells in sufficient numbers that they don’t need to reproduce in the patient’s body, which Howard thinks reduces risk for inflammation. In a recent trial, 15 people with autoimmune diseases received the Cartesian CAR T treatment; two-thirds saw their symptoms improve and none suffered long-term serious side effects.
Treating CAR T Sticker ShockBeyond side effects, the other major challenge facing CAR T therapy is its price tag, which reaches hundreds of thousands of dollars including hospital stays, cell engineering, and other expenses.
The treatment would likely be cheaper, and simpler, if scientists could eliminate the need for personalized engineering of each patient’s own cells and instead use donor cells, or if they could cut out the step of engineering and growing the cells in a laboratory. Lunning says he is eyeing up-and-coming procedures that would modify a person’s T cells within their own body instead of doing the genetic engineering in a lab.
Researchers are even farther along with a version of CAR T that uses healthy donors as a source of T cells. These could then be used by many patients in an “off-the-shelf” approach. It’s a method that has its own challenges, because of the immune mismatch between donor and patient cells that would lead them to attack each other. This problem can be overcome with additional genetic modifications to the donated T cells that prevent recipient and donor systems from recognizing each other as foreign, says Bing Du, an immunologist at East China Normal University in Shanghai who’s among many researchers working on this approach. Du estimates a lab could make CAR T cells for more than 1,000 patients from a single donor’s blood cells, at significant cost savings.
This kind of off-the-shelf CAR T therapy is what Janisch-Hanzlik of Nebraska received, under Lunning’s care, in 2025. The study organizers at TG Therapeutics expect to complete their research in early 2029.
Janisch-Hanzlik ended up sailing through the follow-up without side effects. A couple of months after the infusion, she was watching TV when she noticed she no longer needed special glasses to correct double vision. She started forgetting to bring her cane when moving about her house or going grocery shopping; she didn’t need it. Now, nearly a year since the treatment, she rarely falls and no longer requires a daily, three-hour nap. She recently enjoyed a trip to the Grand Canyon and looks forward to spending more time with her grandchildren.
She does still have symptoms, including weakness in her right leg, numbness and tingling in her feet, and difficulty finding the right word when speaking. She asks her doctors if they think she’s going to get better, stay the same or get worse again.
“I have been told so many times, ‘We don’t know, you’re the first. We’re just going to have to wait and see,’” she says. “I definitely am thankful for every day I have.”
This article originally appeared in Knowable Magazine, an independent journalistic endeavor from Annual Reviews. Sign up for the newsletter.
The post A Revolutionary Cancer Treatment Could Transform Autoimmune Disease appeared first on SingularityHub.
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