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Výprava do druidských hor od studia Paraglacial zatím funguje v předběžném přístupu, ale už od prvotní verze zvládá ohromit. Nejenom díky zajímavému námětu. Úroveň grafiky se nemá problém rovnat s tím nejlepším, co na poli fantasy světů najdeme i přesto, že se prodává za zlomek ceny novinek.

Today is Microsoft's September 2026 Patch Tuesday, with security updates released for a record-breaking 966 flaws, including two actively exploited zero-day vulnerabilities. [...]

Každý měsíc vybíráme nejlepší mobily v několika kategoriích • Smartphony dělíme podle výbavy a ceny, aby si mohl vybrat každý • Nezapomínáme ani na levné a tlačítkové telefony

Microsoft has released Windows 11 KB5124008 and KB5122880 cumulative updates for versions 25H2/24H2 and 23H2 to fix security vulnerabilities, bugs, and add new features. [...]

Nejnovější funkcí české služby Mapy.com je zobrazení jídelních lístků restaurací. Najdeme ji na webu a také v mobilních aplikacích pro Android (26.9.0 a 26.9.1) a iOS (iOS 26.8.2 a 26.9.0). Menu ale musíte hledat pod lupou, protože kouzelné tlačítko Jídelní lístek není dostupné u všech restaurací. ...

Elderly mice on the popular weight-loss drug semaglutide aged slower and lived longer, mimicking the longevity effects of caloric restriction.

It’s a hot GLP-1 drug summer. Semaglutide—better known as Ozempic and Wegovy—seems to be everywhere. The blockbuster weight loss aid mimics a natural hormone that tells the brain “you’re full,” making it easier to shed pounds without the constant hunger and cravings that make traditional dieting miserable.

The drug may also have longer effects. A new study in mice suggests that starting semaglutide in old age extends lifespan roughly 12 percent. The mice regained their curiosity and memory and improved on myriad age-related hallmarks. Chronic inflammation cooled. Senescent “zombie cells” dwindled. Their genomes and proteins became more stable, and the hippocampus—a brain region crucial for learning and memory—sprouted new neurons.

The findings are reminiscent of calorie restriction, a way to boost longevity and stave off age-related health problems, at least in lab animals. But sticking to a diet for years, let alone decades, is tough. Scientists have long searched for a drug that could deliver some of the benefits without hunger pangs. Semaglutide seems to fit the bill, with surprising perks beyond dieting.

“If these results from mice hold true in people, this is a promising hint that people taking GLP-1R agonists [GLP-1 drugs] may have an age-slowing benefit as well as benefits to reducing diabetes and obesity,” said Tara Spires-Jones at the University of Edinburgh, who was not involved in the study.

But don’t go ordering GLP-1 drugs online just yet. The study used inbred female mice, whose physiology differs from that of women aging through or beyond menopause. Rapid weight loss in people taking these drugs can also reduce lean muscle, potentially increasing fragility in older people. And while GLP-1 drugs are already being tested in the battle against neurodegenerative disorders, whether they sharpen the aging brain remains an open question.

Still, longevity researchers are cautiously optimistic.

“The findings reframe a key question that has often been asked back to front,” wrote Maria Fernandez and Rafael de Cabo at the National Institute of Aging, who were not involved in the study. “Rather than considering the broad health benefits of GLP-1 drugs as something to be explained one disease at a time, these results suggest that the positive effects have a common cause: slowed aging.”

Fountain of Youth

One way to live healthier and longer is seemingly mundane: adopt a healthy lifestyle.

Diet and exercise have repeatedly been linked to better health in our twilight years. As we age, our bodies slowly break down. Damage and mutations accumulate in DNA. Telomeres, the protective caps at the ends of chromosomes, grow shorter, contributing to genomic instability. The molecular switches that turn genes on or off go haywire, and our cells become less able to make working proteins and clean up damaged ones.

There’s more. Mitochondria, the cell’s power plants, struggle to produce energy and leak toxic molecules. Damaged cells stop dividing, lose their function, but stubbornly refuse to die. Instead, they leak a toxic chemical soup that damages tissues. Chronic inflammation flares, and stem cells run out of steam, making it harder for the body to regenerate or repair itself.

Together called the hallmarks of aging, this laundry list has long challenged scientists looking for a silver bullet against the march of time. They have discovered some exotic options. Transferring components of young mice’s blood to older recipients has rejuvenated faltering hearts, kidneys, and brains. And clearing senescent “zombie” cells with drug cocktails or genetic engineering has attracted billions of dollars in investment.

But perhaps the most studied, and most robust, intervention is caloric restriction. In flies, rodents, and other lab animals, slashing energy intake without causing malnutrition has repeatedly extended lifespan and delayed multiple age-related diseases. Restriction triggers broad changes, including improved metabolism and insulin sensitivity. It also helps prevent damage to cells. In humans, moderately reducing calories seems to improve heart health and slow the speed of biological aging.

Sticking to a diet for years on end, however, is hardly sustainable.

Cheat Code

GLP-1 drugs may make it easier.

Originally designed to control blood sugar and appetite, the drugs have also shown promise for reducing rates of cardiovascular, kidney, liver, and neurodegenerative diseases, at least in people with obesity or Type 2 diabetes. Clinical trials are now exploring their effects in people with metabolic liver disease, which becomes more common and consequential with age.

Not all these effects can be explained solely by weight loss, raising a bigger question: How can a single class of drugs influence so many seemingly unrelated conditions that often crop up with age?

“If GLP-1 medications slow down the aging process itself, a wide range of clinical benefits is

exactly what would be expected, because aging is the root of most chronic diseases,” wrote Fernandez and de Cabo.

To test that theory, the team gave daily semaglutide injections to 20-month-old female mice—roughly comparable to women in their early-to-mid 60s—for as long as they lived.

Compared to a group of mice given saline, the treated mice lived an average of 834 days, versus 724 days for a control group. Both groups could feast on standard chow to their hearts’ content. After just three months of treatment, the mice taking semaglutide were more lively and curious than their peers. They readily explored new environments, balanced better on a skinny rotating rod, ran faster on a tiny treadmill, and solved mazes more quickly.

Under the hood, semaglutide blunted the hallmarks of aging across the board. Stem cells in the bone marrow and hippocampus sprouted, suggesting renewed regenerative capability. DNA damage and protein and energy dysfunction declined. Zombie cells partially disappeared.

The results weren’t simply a consequence of eating less. In another three-month experiment, the team compared the drug with a calorie-restricted diet that cut energy intake by 24 percent—the same reduction seen in the semaglutide-treated mice.

The drug seemed to have a leg up. Compared with caloric restriction, it produced more improvement in cognition and blood sugar control, without the metabolic adaptations normally driven by hunger, such as lowered energy expenditure. The mice also showed fewer signs of hunger. They ate on a normal schedule rather than prowling for food before feeding time and gobbling rations once available.

Genetic sequencing of the liver found semaglutide triggered similar molecular signaling pathways as caloric restriction, like for example, those that sense nutrient availability, cell stress, and proteins involved in longevity. Both interventions tamped down inflammation and boosted genes involved in handling fats, but they didn’t follow the exact same biological playbook.

The findings raise the “intriguing question of whether GLP-1 drugs target an alternative biological route into aging that has its own side effects and therapeutic ceiling,” wrote Fernandez and de Cabo. Exactly how that route works remains unclear, but the team is eager to find out.

The findings are promising, but the study also has major limitations. It didn’t directly compare dieting and semaglutide for lifespan extension. And because gender affects the aging process, the team will need to see if the results hold in males. Then there’s the potential loss of lean muscle, a serious concern for people who are already frail or saddled with age-related health conditions.

Even so, “semaglutide is probably the best caloric-restriction mimetic I have seen,” Tim Rhoads at the University of Wisconsin–Madison , who was not involved in the study, told Chemical and Engineering News.

Untangling semaglutide’s bonus effects could ultimately reveal new ways to slow—or even rewind—aging’s ticking clock.

The post Could GLP-1 Drugs Help You Live a Longer, Healthier Life? appeared first on SingularityHub.

Televizory zlevňují a velké úhlopříčky už dávno nejsou luxus. Přesto má smysl připlatit si za vyšší střední a prémiovou třídu. Vybrali jsme 13 modelů, které dnes dávají smysl – od absolutní špičky až po nejlepší poměr cena/výkon. Vždy zohledňujme aktuální ceny a celkovou kvalitu.

The ShinyHunters extortion gang claims it breached an online platform for the Florida Department of Motor Vehicles database known as "DAVID" and stole over 200,000 records about drivers in the state. [...]

OpenAI is investigating an ongoing incident causing ChatGPT image generation failures and delays when uploading files. [...]

A previously undocumented financially motivated threat actor has been linked to attacks targeting Brazilian financial institutions since at least March 2026. Cybersecurity company CrowdStrike is tracking the Brazil-based activity cluster under the name Slim Spider. "The adversary demonstrates deep operational knowledge of Brazilian financial infrastructure, including the instant payment

A previously undocumented financially motivated threat actor has been linked to attacks targeting Brazilian financial institutions since at least March 2026. Cybersecurity company CrowdStrike is tracking the Brazil-based activity cluster under the name Slim Spider. "The adversary demonstrates deep operational knowledge of Brazilian financial infrastructure, including the instant payment Ravie Lakshmananhttp://www.blogger.com/profile/[email protected]

Boston Scientific says that last month's cyberattack caused enough disruption that it is unlikely to meet its sales growth and adjusted earnings guidance for either the third quarter or the full year. The medical device giant disclosed the expected financial hit in an SEC filing published Tuesday, two weeks after an intrusion knocked systems offline and disrupted operations worldwide. Boston Scientific detected unauthorized activity on its network on August 25 and took some systems offline as it scrambled to contain the attack. At the time, it said the resulting outage had affected business applications used to process and ship customer orders, but couldn't say what the incident would ultimately cost it. It now has a better idea, and the news isn't great. In its latest filing, Boston Scientific said the disruption is likely to have a "material impact" on its third-quarter and full-year results, leaving it unlikely to meet the net sales growth and adjusted earnings-per-share guidance ranges issued in July. Boston Scientific expects to recover some of the affected revenue as it clears the backlog, but does not yet know the incident's full financial impact. The company plans to update its operational and financial outlook when it reports third-quarter results on October 28. The recovery is at least moving along. Boston Scientific said it had substantially restored its distribution network, with major distribution centers processing and shipping orders at or above normal levels. Its sterilization facilities are operational, and manufacturing has resumed at most sites worldwide. An interruption affecting new patient activations for remote monitoring of certain cardiac devices has also been resolved, according to the filing. The company has previously said it knows of no impact on devices that are not connected to a Boston Scientific network. Still, the company hasn't put a date on when everything will be back to normal. It said some systems and business applications remain affected and that it cannot yet estimate when it will achieve full operational recovery. Boston Scientific said it has identified no evidence of ongoing unauthorized access to its systems, although its investigation remains underway. Exactly what happened remains a mystery. The company has yet to say how the attackers got in, whether ransomware was involved, who was responsible, or whether any data was stolen. No ransomware group had publicly claimed responsibility at the time of writing. Boston Scientific said it does not expect the incident to materially affect its long-term financial condition, even if its outlook for 2026 looks considerably less healthy since intruders breached the network. ®

SunBooster je kompaktní zařízení, které se připevní na horní hranu monitoru a při práci na počítači na člověka září patentovanou technologií SunLED. To jsou diody emitují světlo blízké infračervenému pásmu (NIR, Near-Infrared), tedy tu složku slunečního světla, kterou na cestě do interiéru ...

Linux can move a network packet's data in memory while some networking code still holds its old address. That saved address is called a pointer. A patch and maintainer discussion posted on Sep 7, 2026 describe how that mismatch can make an IPv6 Segment Routing eBPF action write to memory that Linux has already released. Segment Routing steers packets through specified network waypoints; eBPF lets small programs run inside the kernel to customize tasks such as packet handling.

Microsoft says the August 2026 security update may trigger 0xc0000409 errors on Windows Server 2016 systems where the Compatibility Appraiser diagnostic service is enabled. [...]

Secure by design videoconferencing products may be vital for customer trust and operational resilience, but if they aren't usable, organizations are on a hiding to nothing. Videoconferencing security is no longer a routine item on the IT checklist. Organizations now rate security as their most important purchase criterion (31 percent) when selecting such products, ahead of price (26 percent) and quality (25 percent), according to IDC. The implication, is that security and privacy are no longer optional. Instead, they are the foundation of effective meeting room solutions, enabling safe and unified collaboration. Yannic Laleeuwe, marketing director for Barco's ClickShare, agrees. Collaboration and videoconferencing solutions have become "mission-critical business systems" in her view, because they process significant volumes of the most sensitive corporate information while sitting on crucial networks and cloud services. "Historical security incidents, combined with the rapid growth of hybrid work since the COVID-19 pandemic, have demonstrated that weaknesses in these platforms can lead to data breaches, operational disruption, regulatory exposure, and loss of customer trust," Laleeuwe explains. "Consequently, security has evolved from a technical consideration to a strategic procurement and governance priority for organizations worldwide." The IDC study indicates that most businesses' biggest security concern is exposure to cyberattackers, which can lead to incidents such as malware propagation (47 percent). Next on the list is devices falling out of compliance because of missing patches and updates (39 percent). Third comes risky employee behavior, which can result in inadvertent, or even deliberate, data exposure (37 percent). These issues become particularly problematic in a hybrid working environment, where meeting rooms have evolved into highly connected, distributed spaces. Employees now expect ready access to business applications, data, and collaboration tools wherever they happen to be working. An expanding attack surface Such demands expand the potential attack surface for meeting room technology. Users, devices, cloud services, home networks, and collaboration platforms all become endpoints on the corporate network, even though many were never designed to operate in an enterprise IT context. That leaves them as potential entry points for attackers. "Collaboration solutions are particularly attractive targets because they are connected to corporate systems and frequently process sensitive information, including intellectual property, strategic discussions, and customer data," Laleeuwe points out. The situation grows worse when IT management becomes too decentralized. "As organizations adopt hybrid working and distributed IT models, maintaining centralized visibility and governance becomes increasingly challenging as local teams may implement different technologies, configurations, and processes," Laleeuwe adds. She acknowledges that certain operational responsibilities can, and should, be handled locally to support business agility and regional requirements. But complete decentralization often leads to inconsistent security controls, fragmented risk management, and reduced ability to detect and respond to cyber threats across the enterprise, she warns. Mounting global regulatory pressure On top of that, international regulatory pressure on both security and security technology is producing an increasingly complex legislative landscape, because policymakers and industry bodies now recognize that cyber incidents can threaten critical services, national security, and even economic stability. In Europe alone, legislators have introduced a raft of legal frameworks, including the European Union's Network and Information Security 2 Directive, which mandates strict risk management and incident reporting for medium-to-large organizations across 18 critical sectors. Other legislation, such as the Radio Equipment Delegated Act, is intended to secure wireless equipment against cyberattackers. Another, the Cyber Resilience Act, provides safeguards for businesses and consumers when purchasing any hardware or software products connected to a network. Global standards such as ISO/IEC 27001 now define best practice for information security and risk management, and offer organizations a framework for operational trust. In other words, organizations must now embed security considerations across all their key activities, which include governance, risk management, supply-chain management, and incident response. They also need to make certain that their technology providers integrate security across the entire lifecycle of their products and services, from design and development through deployment and end-of-life support. Non-compliant collaboration and videoconferencing technology no longer simply poses an organizational risk. It may also prove unusable. Security as a pre-requisite for doing business The upshot, Laleeuwe says, is that cybersecurity has evolved from a "voluntary best practice into a legal and business obligation, making security a prerequisite for market access, customer trust, operational resilience, and long-term competitiveness." Even so, compliance and strong security enablement cannot be allowed to come at the expense of usability, particularly in a hybrid workplace. If collaboration tools are perceived as too complex or restrictive, employees will find workarounds, and the organizational security risks rise rather than fall. To tackle the problem, IT teams must weigh several factors. From a people perspective, the biggest challenge is behavioral. "Users naturally seek convenience, so continuous security awareness, training, and a strong security culture are essential to encourage secure behavior without hindering productivity," Laleeuwe explains. Clear, transparent, and well-defined processes matter just as much, because they ensure security and compliance requirements are consistently understood and implemented across the organization. Why secure by design matters From a technology perspective, the focus must move away from perimeter-based security towards a zero-trust approach in which every user, device, and connection is continuously verified and protected. In product design terms, it is just as crucial that meeting room technology rests on secure-by-design principles, so that compliant, state of the art security controls are integrated into systems from the outset rather than bolted on as an afterthought. As Laleeuwe says: "Security by design reduces the likelihood and impact of vulnerabilities, simplifies compliance with emerging cybersecurity regulations, and strengthens customer trust. It also lowers the overall cost of ownership because identifying and resolving security issues during design and development is significantly more efficient and less costly than remediating incidents, recalls, or security breaches after deployment." Barco's ClickShare wireless video conferencing, presentation, and collaboration solution is a classic example of this approach. Barco developed it from the ground up using secure architecture design and coding. It also includes proactive vulnerability management that continuously monitors newly disclosed vulnerabilities and issues risk-based security updates. That process cuts the system's exposure to both known and evolving threats. Automatic deployment of those security updates simplifies maintenance and helps organizations consistently protect large fleets of devices. Users can focus on the task in hand rather than managing the technology or calling in specialist cybersecurity experts when things go wrong. "The advantage is that security is handled largely in the background, reducing the risk of human error, improving adoption, and allowing people to concentrate on productive collaboration rather than system administration," Laleeuwe points out. "So, ClickShare provides effective protection while minimizing friction for end users." A changing security landscape That matters, she says, because compliance is now a shared responsibility that spans organizations, their technology providers, integrators, and increasingly the broader supplier ecosystem. Organizations, for instance, must hold themselves accountable for securely operating and governing their own environments, even if doing so requires a change in focus. As Laleeuwe explains: "The implication for IT departments is that they must evolve from being solely operational service providers to becoming governance and coordination functions that establish common security standards, policies, monitoring, and oversight across the organization." Technology providers, in contrast, are responsible for delivering and maintaining secure products throughout their lifecycle. They also have a critical part in monitoring vulnerabilities in their platform's software components, providing timely security patches, and transparently notifying customers and downstream partners about relevant security risks. Integrators, lastly, are responsible for deploying and configuring solutions in line with current security and compliance requirements and guidance. "No single party has complete control over the entire technology stack, making supply-chain security and collaboration essential for maintaining a secure and compliant environment," Laleeuwe says. "The most effective approach is therefore a clear allocation of responsibilities across all parties, supported by transparent communication, vulnerability disclosure, and coordinated risk management." Another element of security success is aligning organizational measures such as clear accountability, security awareness, and shared ownership of cybersecurity with technology that provides centralized visibility into assets, vulnerabilities, compliance, and security events. As Laleeuwe concludes: "This consolidated view enables organizations to better understand, measure, and manage risk across the entire enterprise while maintaining the flexibility needed by local teams. The most effective approach balances local operational autonomy with centralized governance, ensuring consistent security, compliance, and strategic control without compromising business efficiency." Sponsored by Barco.

SAP has addressed 20 vulnerabilities across multiple products in its September 2026 security updates, including a maximum-severity memory corruption flaw in the SAP Kernel code. [...]

Whoever took nearly 4,000 bitcoin from the Liquid Network on Sunday, September 6, returned 3,400 of it the next day, Bitcoin's public record shows. About 598.5 bitcoin has not come back. Liquid is a Bitcoin sidechain that holds real bitcoin to back a token called L-BTC. The network is still paused, so holders cannot turn that token back into bitcoin. The 3,400 bitcoin was sent to a&

Whoever took nearly 4,000 bitcoin from the Liquid Network on Sunday, September 6, returned 3,400 of it the next day, Bitcoin's public record shows. About 598.5 bitcoin has not come back. Liquid is a Bitcoin sidechain that holds real bitcoin to back a token called L-BTC. The network is still paused, so holders cannot turn that token back into bitcoin. The 3,400 bitcoin was sent to a&Ravie Lakshmananhttp://www.blogger.com/profile/[email protected]

Falešná výstraha ve Windows tvrdí, že antivirový program nefunguje • Integrovaná ochrana MS Defender přitom stále funguje správně • Vývojáři připravují opravnou aktualizaci pro všechny zasažené verze