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NVIDIA na konci ledna vydala v beta verzi nativního linuxového klienta své cloudové herní služby GeForce NOW. Včera oznámila ukončení beta verze a oficiální podporu Linuxu.

You're not alone if you just received an "Apple Threat Notification" saying it detected a "mercenary spyware attack targeted at your iPhone." [...]

Sugar damage in the body was thought to be irreversible. But the new enzyme made 75-year-old tissue look chemically like a 30-year-old’s.

The scent of fresh bread straight from the oven is intoxicating. As sugars and proteins react under heat, they create compounds that give golden-brown crusts their rich aroma. Called advanced glycation end products (AGEs), these molecules also form inside us. Our bodies are essentially ovens running at around 98 degrees Fahrenheit, and AGEs slowly build up over decades. They stiffen bouncy, elastic tissues and trigger lasting inflammation.

One of the hallmarks of aging, AGEs drive a range of age-related problems, increasing the risk of heart disease, diabetes, and eye and kidney troubles. In theory, clearing them out could turn back the clock. But previous attempts have failed, leading some scientists to suspect that the damage is irreversible. Once AGEs form, they stay.

Or maybe not.

A team at Revel Pharmaceuticals in San Francisco and colleagues took a new approach: They designed a synthetic version of an enzyme found inside microbes that targeted the most abundant type of AGE in several human tissues. In tissue from a 75-year-old donor, the enzyme reduced AGE levels to those seen in a 30-year-old, potentially giving the cells and their surrounding scaffold a chance to repair and rebuild.

“This work establishes that damage to aging proteins previously thought to be irreversible can be repaired,” wrote the team. Study author and Revel CEO Aaron Cravens added in a press release: “More work is needed, but these results alter the starting assumption for how we think about this fundamental aspect of the aging process.”

Rusting Away

AGEs are often nicknamed the body’s rust. They coat structural proteins, and like rust eating away at a car, gradually damage them. Scientists discovered AGEs in the 1980s and have sought ways to scrub them away ever since.

Most aging research has focused on keeping cells healthy. The scaffolding surrounding those cells has received far less attention, even though it makes up roughly 70 percent of the body. These structural materials are especially long-lived. It takes the body 15 years to replace half of its collagen, for example. That longevity comes with a price. The longer these proteins stick around, the more likely they’ll incur damage from accumulating AGEs. The result isn’t just loose skin, weakened tendons, and creaky joints. The heart, kidneys, brain, and eyes also suffer.

Scientists have developed drugs to intervene. Some are able to stop new AGEs from forming but fail to clear those already embedded in tissue or restore damaged proteins. Attempts to develop enzymes that could cut them apart have also been unsuccessful, largely because there aren’t obvious natural enzymes in the body to use as a starting point for protein engineering.

The authors of the new study looked outside the body, starting with an unusual idea. Human remains, including AGE-laden proteins, are eventually decomposed by microbes. The team reasoned these bugs may harbor enzymes that can be engineered to clean up the molecular debris while we’re still alive.

Needle in a Haystack

For the search, the team focused on CML, the most abundant type of AGE.

CML is both notoriously stubborn and detrimental to our health. It triggers cells to release inflammatory molecules that stiffen tissues and damage microglia, the brain’s immune cell guardians, contributing to cognitive decline during aging.

“We believe you can remove [CML damage] enzymatically, by going in and developing these lawnmower enzymes that can just cut and clip these changes off of the proteins,” Cravens told The Scientist.

The team screened DNA sequences from over 50,000 microbes with AI and predicted the structures of the enzymes they encoded. They narrowed the candidates by looking for those capable of reaching CML buried within larger proteins like collagen. The winner came from a type of bacteria that thrives in geothermal hot springs.

The enzyme could cleave CML molecules, but barely. To boost its effectiveness, the team turned to directed evolution, a Nobel Prize-winning technique that mimics natural evolution at breakneck speed. After five evolutionary rounds and more than 500 million variants, they landed on CMLase, an engineered enzyme over 10 times more efficient than its ancestor.

To test its activity, the team created CML-laden versions of several proteins, including collagen, retinal proteins, and hemoglobin, which carries oxygen in blood. Initial test-tube experiments showed the enzyme worked as expected. It stripped away the chemical modification and restored the proteins’ original structures, as if they had never reacted with sugar. Think Rust-Oleum, but for damaged proteins.

But does it work in actual tissues?

Mice might seem like the obvious next test, but their short lifespans make them poor models for decades of accumulated molecular damage. Instead, the team tested CMLase on thin slices of donated human tissue.

In aortic tissue—the aorta is the body’s largest blood vessel—from a 75-year-old donor, the enzyme slashed CML by roughly 70 percent, bringing levels down to those seen in a 30-year-old. Skin and eye lens proteins from a 64-year-donor also showed significant reductions.

“We were pretty floored,” said Cravens.

Chemical reversal, however, isn’t the same as tissue rejuvenation. It’s still unknown if stripping away CML can actually restore tissue. But the finding challenges a decades-long assumption this kind of molecular damage can’t be treated. It also highlights long-ignored structural proteins as a crucial part of damage repair during aging, paving the way for new treatments.

An enzyme like CMLase could, in theory, be formulated as eye drops to clear CML from the lens or be used to plump up the skin’s protective barrier or restore hearts and kidneys. It would be especially valuable for people with type 2 Diabetes, who accumulate these compounds faster than usual.

Plenty of roadblocks remain. Safety is a concern. Because CMLase evolved from a bacterial protein, the body could label it foreign and launch immune attacks (especially with repeated doses). The body’s own enzymes could also break it down before it has a chance to work. And the enzymes will have to tunnel through a dense protective biological sheath that surrounds organs to reach their target. Work is underway to improve its activity, stability, and safety.

But the team is already looking beyond CMLase. Engineered enzymes could potentially erase other forms of molecular damage once considered permanent. CML is just one member of the AGE family. If the approach works, other targets could follow and one by one, they might chip away at the molecular scars of time.

The post Designer Enzyme Strips Decades of ‘Rust’ From Aging Human Tissue appeared first on SingularityHub.

Byla vydána nová verze 3.5.0 nástroje pro inkrementální kopírování souborů rsync (Wikipedie). Přehled oprav a vylepšení v souboru NEWS. Řešeno je 33 zranitelností.

If you want to record whatever you do on a computer, send those records to OpenAI, use more ChatGPT tokens, and increase your vulnerability to prompt injection, then OpenAI has something for you. It's called Computer History, an opt-in way to record your computer interactions across apps and websites as memories organized on a timeline. Why would you want to do so? Maybe you found Chronicle, the predecessor of Computer History which compiled similar histories using screenshots, a bit too intrusive but don't mind Computer History's approach – recording input events and storing them unencrypted locally for 48 hours (or more), with a brief visit to OpenAI's servers. Maybe you're not bothered by the warning OpenAI includes in its documentation: "Computer History files can contain sensitive information. They are not encrypted by Computer History, and other programs running as your macOS user may be able to access them." Perhaps, having given OpenAI's Codex and GPT Work the run of your computer, you're already sold on the suggestion that storing your computer activity in memory files and arranging those interactions in a timeline will improve ChatGPT responses, surface opportunities for automation, and make it easier to resume prior work. Computer History is, to put it bluntly, a keylogging and event capture system. There was a time before eyeglass cameras, license plate readers, surveillance capitalism, and police drones when such snooping might have provoked an outcry from privacy advocates. But the tech industry has found it can outsource surveillance to its own customers and in so doing make the panopticon harder to protest once it becomes a personal choice. "Computer History creates an interaction-event stream from allowed apps and websites," OpenAI's documentation explains. "Events can include clicks, typing, keyboard shortcuts, app switches, and context that macOS exposes through its accessibility system. Computer History periodically turns these events into text summaries and local memory files." The AI biz makes a point of noting that Computer History does not capture screen images, microphone input, or system audio. Nor does it capture private-mode browsing. Off by default, Computer History is available for ChatGPT Pro, Business, and Enterprise users in the ChatGPT desktop app on macOS. Pro users can enable it individually; Business and Enterprise users need an admin to approve it. It's not available currently in the European Economic Area (EEA), Switzerland, or the United Kingdom or to those accessing ChatGPT via API key or Amazon Bedrock. There are circumstances in which OpenAI suggests Computer History users might want to suspend the service if they have some scruples about capturing user activity in apps and websites without permission. "Turn it off during communications with other people unless you have their prior express consent," the company advises, perhaps in acknowledgement of legal risk. "Consider pausing it or excluding apps that contain sensitive health, financial, or personal information." Computer History interaction events are supposed to be saved locally for up to 48 hours before being deleted by ChatGPT and Codex. Events, however, get sent to OpenAI servers to generate memories, and those may be stored locally for longer periods of time and may be used in future chats that get passed back to OpenAI. "OpenAI does not retain those event files after processing unless required by law and does not use them for training," the company says. While it has opposed demands for chat logs, it has nonetheless provided chat logs in response to legal process. Computer History adds cost because it uses tokens during the summarization of activities and the creation of memory data. It also expands the prompt injection attack surface. "Computer History increases the risk of prompt injection from content in apps and websites," the company says. "For example, if you visit a website containing malicious instructions, ChatGPT or Codex might follow those instructions." But at least you get a nice timeline of your recent activity. ®

Organizace Apache Software Foundation (ASF) vydala verzi 31 integrovaného vývojového prostředí a vývojové platformy napsané v Javě NetBeans (Wikipedie). Přehled novinek na GitHubu. Instalovat lze také ze Snapcraftu a Flathubu.

Astronomové zaznamenali jednu z nejvzácnějších událostí spojených s černými dírami. Objevili dosud nejpřesvědčivější důkaz toho, že Betelgeuse má společníka. Elektrická pole fungují jako fyzikální přepínač proteinů.

Falešný policista vám oznámí napadení účtu, pošle průkaz a úředně vypadající dokumenty. Následují dlouhé telefonáty, převod peněz na „bezpečný účet“ nebo žádost o úvěr, který má údajný útok zastavit. Moderní bankovní podvody nestojí především na technických dovednostech. Jejich hlavní zbraní je psychologická manipulace.

Uživatel předal k pozáručnímu servisnímu zásahu konzoli Playstation 5 z důvodů výrazného přehřívání. Servis zjistil, že tekutý kov částečně stekl mimo křemík SoC a také se dostal na chladič…

Centromery, které drží pohromadě chromozomy od obou rodičů, hrají klíčovou roli při rozdělování chromozomů během dělení buněk. Navzdory značnému významu byly centromery pro genetiky až doposud velkou neznámou. Nové metody čtení dlouhých úseků DNA otevřely dveře pro výzkum těchto oblastí chromozomů.

V dnešním přehledu novinek mířících do linuxového jádra zaměříme pozornost na Apple a hráče. Podíváme se na novinky v podpoře Apple M4 i posledních x86 Macbooků a také na patche vylepšující produkty Valve či handheld MSI s ultra-mobilním Ryzenem Z2 Extreme, který je standardně dodáván s Windows 11.

Authorities in Ukraine shut down 94 fraudulent call centers across the country that lured people into investment scams or tried to obtain access to bank accounts. [...]

An Akira ransomware affiliate disabled the endpoint detection and response (EDR) solution on a compromised system by restarting the machine into Safe Mode with Networking. [...]

Border Gateway Protocol (BGP) is still trust-based. In the past, a router would announce it originated a block of address space, and its neighbors would take that claim at face value. That trust model is the reason a single misconfiguration or a deliberate false announcement can pull traffic for someone else’s network across the planet, and why routing security has become a core concern for anyone responsible for keeping services reachable. 

The Trump administration is recruiting private security firms to conduct federal government-authorized operations, including cyberattacks, against overseas-based criminal organizations that commit hacks on US persons, organizations, or government entities.

In a National Security Presidential Memorandum issued Thursday, US President Donald Trump directed the National Coordination Center (NCC), which operates under the Homeland Security Task Force, to develop a program for conducting specific cyber operations that combat foreign transnational criminal organizations (TCOs). The Departments of Justice and Homeland Security will provide oversight. The lynchpin of that program is bringing in private sector companies to participate.

Devil will be in the still-undefined details

A fact sheet that accompanied Thursday’s memo listed ransomware, sextortion schemes, phishing campaigns, financial fraud, and impersonation scams as activities eligible for private-sector security firms to target. The memo said such firms could “conduct Cyber Surveillance Operations and Cyber Effects Operations” against “cyber-enabled” TCOs. Such groups are defined as “any foreign group that conducts cyber-enabled crime against the United States Government, a United States person, or United States interests, and that is not an institutional part of a foreign government or wholly operated under a foreign government’s direction.”

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A newly disclosed zero-day flaw in GeoServer is seeing active exploitation efforts, per watchTowr. The vulnerability, which has yet to be assigned a CVE identifier, is an SQL injection vulnerability in the open-source platform that can lead to remote code execution (RCE). The security defect remains unpatched. It was first disclosed on August 12, 2026, at 10:46 UTC, by a researcher named @Ravie Lakshmananhttp://www.blogger.com/profile/[email protected]

Some weeks have one big security story. Others bring many smaller updates that are easy to miss but still matter. This week has plenty of them, covering cloud services, AI tools, malware, data breaches, scams, and new attack methods. The latest ThreatsDay Bulletin puts all of these short updates in one place, so you can quickly catch up on what happened, what changed, and what security teams Ravie Lakshmananhttp://www.blogger.com/profile/[email protected]

The Jewelbug hacker group has been carrying out espionage operations targeting governments and militaries while also engaging in cryptocurrency fraud. [...]

Samsung vysvětluje automatický pokles rozlišení z 24 na 12 Mpx • K tomuto přechodu dochází při vysoké teplotě či použití zoomu • Pro zachování vyššího rozlišení udržujte telefon v chladném prostředí

Microsoft has released security patches to address a Windows zero-day vulnerability known as "LegacyHive," disclosed after the July 2026 Patch Tuesday. [...]