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Cloudflare wants to provide the operating system for the AI-first enterprise
Traditional operating systems (OS) were built to manage hardware, files, apps, and users on a device, but Cloudflare says the agentic AI era requires a whole new format.
The company this week announced Cloudflare OS, which connects AI agents, enterprise data and context, internal systems, and workflows together in one secure workspace. It is open source and browser-based, sparing companies the need to build all-new infrastructure.
The OS is launching alongside several other new security, identity, spending, and user insight tools that Cloudflare has built for the AI-based workplace.
“Cloudflare OS isn’t a traditional desktop OS,” said Rita Kozlov, VP of product at Cloudflare. “It reimagines the workplace computing environment for AI.”
Open source OS runs in a browserCloudflare OS serves as a secure, AI-equipped workspace that is plugged into internal company systems. Available now through Cloudflare’s open source repository, it is accessible directly in a browser, and runs inside an enterprise’s Cloudflare account.
“It is a browser-based workspace that begins with a conversation,” Kozlov explained. Users can ask an agent to research, create slides, spreadsheets, and documents, build full-stack apps, or automate workflows without the need for a terminal. Those outputs are then shareable, but kept in isolated databases with access controls.
Enterprises will soon be able to access the OS directly through Cloudflare or via a “select group” of partners that will build tailored offerings on Cloudflare’s architecture, the company says. Because it is open source, organizational processes, internal system connections, and context aren’t locked into a vendor product or AI model provider. Customers can use whatever models they choose.
Cloudflare OS is built on Cloudflare Workers, Dynamic Workers, Durable Objects, and Access, the company’s zero trust network access (ZTNA) tool that verifies every user and request. Agents start with zero permissions by default and are only granted access to tools required for a specific task. Organizations configure their own Access policies, models, branding, skills, and integrations, Kozlov explained.
Governed connectors known as gatekeepers give admins control over what AI can see, what it can change, and when the system needs human sign-off. They can also control budgets, set rate limits, and delegate tasks to different models.
“Because agents act on people’s behalf and produce work others can access and modify, they require a new security model,” Kozlov said. Thus, Cloudflare OS tracks the resources an agent requires so the right access controls follow its work when it is shared.
Cloudflare initially built the OS for internal use, and employees “across every team” use it daily. Kozlov estimated that, over the last 30 days, internal users have used it to create more than 4,000 apps, automations, and tools. Over that same period, she claimed, the company’s sales team saved an estimated 10,000 hours by automating previously manual tasks like territory planning and proposal creation.
“We open sourced Cloudflare OS so any organization can build ‘Your Company OS,’” Kozlov said. Open source is critical because “you cannot put your company into software you do not own. Organizations need to be able to inspect the platform, customize it, connect their own systems, and make it their own,” she explained.
A more cohesive bundleCloudflare deserves credit for packaging Cloudflare OS as an operating system, noted tech analyst Carmi Levy.
“This very much is not Windows, macOS, or Linux, and it isn’t an operating system by its common definition,” he said. “But Cloudflare’s use of this terminology implies familiarity to enterprise IT buyers.”
This makes for an easier discussion as enterprises struggle to understand how to best incorporate AI-related platforms and workflows into infrastructure that wasn’t initially designed for it.
Microsoft has marketed the combination of its Azure, Entra, Fabric, Windows, and Microsoft 365 offerings as an operating system of sorts, but hasn’t pulled all the pieces into a common brand, Levy said. And Google’s Gemini, Workspace, Vertex AI, and Cloud Run are “circling similar territory.”
But, he noted, Cloudflare OS is “more cohesively bundled” and infrastructure-focused, offering a single pane of glass platform for buyers worried about stitching together otherwise disparate AI-aware networking pieces. The company recognizes that AI introduces new architectural realities such as inference and model routing “over and above” traditional OS core competencies.
“While competing offerings generally leave the infrastructure heavy lifting to enterprise decision-makers, Cloudflare is marketing itself as a single-source vendor, which potentially frees IT planners from having to integrate all the AI pieces on their own,” Levy said.
An infrastructure-first, application-agnostic approach means Cloudflare OS can coexist with whatever AI applications already exist in an enterprise, he said. It will “play nice” with OpenAI, Anthropic, Google, Microsoft, Meta, or open source layers, allowing employees to begin working in familiar workflows after sign-in.
“Its open-source architecture also minimizes the potential for vendor lock-in as enterprises gradually figure out how to evolve their stacks to align with new AI-era realities,” Levy said.
Managing identities and budgets for both humans and AIAs AI agents emerge across the enterprise, tracking their use can be challenging, causing problems from both a security and a spend standpoint. Along with Cloudflare OS, the company has launched a way to address this issue with its new Identity-Aware AI Gateway, now in beta.
Also integrated with Access, the offering gives admins visibility into what users (both human and AI) are requesting from AI models. It allows security teams to set up custom domains in front of their gateways and replace shared API keys by integrating with their identity provider, like Okta or Entra, and ZTNA infrastructure, Cloudflare explained.
Every request is tied to Access-verified identities, and enterprises can filter each user’s logs, analytics, and spend. IT teams can track redundancies, limit usage rates, and apply filters that strip out employee names, passwords, and other sensitive data before requests go to outside model providers.
A companion feature, AI Spend, tracks every user’s behavior over time to create a baseline of normal AI usage. When spending deviates from that pattern, the system alerts the IT team.
A new tab, User Insights, tracks cost and identifies over-spend caused by activities such as low cache-hit rates or oversized context windows. The capability scores sessions and compares them against account history using a 95th percentile session cost over the previous 30 days, Cloudflare product managers Ming Lu, Kenny Johnson, and Ayush Kumar explain in a blog post. Anything above 2x an account’s 95th percentile is a “strong candidate for anomalous behavior.”
For instance, one Cloudflare customer had an employee who left a rogue AI session running, generating a $30K bill. “User Insights helped them identify the problem and shut off access before the problem was further exacerbated,” Kozlov said.
Cloudflare is also building prompt classification functionality that sorts requests into categories such as coding or writing. This can help enterprises understand what AI is being used for.
“Once business traffic is separated from everything else, personal use becomes visible,” the project managers explained. “From the outside, someone running a side hustle on company time and someone quietly moving data out through a model look the same. Telling them apart is central to catching insider risk.”
Looking at the bigger pictureIdentity-Aware AI Gateway and AI Spend address the visibility problem that has dogged so many recent AI deployments where enterprises failed to monitor usage, Levy noted. Projects “crashed and burned” as users unwittingly blew through token allocations.
These platforms provide single-point visibility into what is being used, how it’s being used, and where the potential lies for raising the productivity bar, he said. They overlay with existing models; in doing so, they enhance security with more precise control over resource allocations, and via automated anonymization protocols that prevent inadvertent sharing of sensitive data.
Ultimately, he said, vendors who free IT from having to independently assemble the pieces of their own AI implementations, and who assist them with answers to AI-specific questions, “will gain advantage over vendors that aren’t looking at the bigger picture.
This article originally appeared on CIO.com.
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Why Do Some People Never Get Cancer? The Answer May Be in Their Blood
Researchers will hunt for antibodies in the blood of people who lived past 100, drank heavily, or smoked—but avoided cancer.
Jeanne Calment was over 122 years old when she passed away. The oldest person in history, she smoked for nearly a century, but never developed cancer.
Why does cancer grow, spread, and become deadly in some people but not others? Even twins, who share similar genes and lifestyles can differ widely in cancer risk. Many factors likely contribute, but a bold new study, called ATLAS, is investigating an unexpected player: autoantibodies.
These immune-system proteins roam our bodies, but instead of attacking pathogens, they mistakenly target healthy cells and tissues. They’re best known for their role in autoimmune diseases, but early evidence suggests they also fine-tune the immune system’s response to cancer. Some appear to weaken immune surveillance, allowing tumors to sprout and flourish. Others may boost anti-cancer immunity by tagging cancer cells for destruction.
Whether they’re friend or foe is far from clear. ATLAS researchers aim to find out by analyzing blood samples from diverse groups of people, including centenarians and people who have escaped cancer despite carrying high-risk gene variants or exposure to risk factors like smoking.
The project hopes to discover why some people are naturally resistant to cancer, which could lead to early diagnostic tests, new therapeutic targets, and more effective treatments. ATLAS may “uncover fundamental principles” of antibody immunity in cancer, wrote the team.
Immune MayhemSince the late 19th century, scientists have suspected the immune system helps keep cancer in check. The idea has since spawned powerful treatments. In CAR T cell therapy, for example, a patient’s own immune T cells are genetically enhanced to better recognize and destroy tumors to cure previously untreatable blood cancers. A similar strategy in macrophages, immune cells that tunnel into tumors and literally engulf them, is now entering early clinical trials.
Far less attention has been given to antibodies. These proteins normally fight pathogens, like viruses. But sometimes they go rogue, taking the form of autoantibodies that attack healthy proteins, DNA, and other molecules. Even healthy people carry a diverse collection of autoantibodies, but most bind only weakly and don’t seem to trigger biological effects.
For decades, these proteins were used mainly to diagnose autoimmune diseases such as rheumatoid arthritis, as they often appear years before symptoms emerge. But more recently, scientists have begun uncovering their broader impact on the immune system. Autoantibodies that attack cytokines, a type of immune signaling molecule, were implicated in roughly 20 percent of Covid-19 deaths, largely because they disabled antiviral defense.
Scientists have since linked them to worse outcomes in several other life-threatening viral diseases, increasing some people’s vulnerability as if they were immunocompromised. Beyond infections, they also neutralize cytokines that protect against inflammatory bowel disease.
Cytokines orchestrate many immune system activities, including inflammation, allergies, autoimmunity—and cancer. Although there’s still little direct evidence that autoantibodies themselves drive or prevent tumors, scientists have found many can recognize cancer-related proteins and are developing methods to detect them as an early sign of cancer.
If autoantibodies can reshape cytokine activity during viral infections, could they also determine who develops, or resists, cancer?
“These discoveries establish that autoantibodies can function as powerful, naturally occurring immune modifiers raising the possibility that similar antibodies may alter antitumor immunity,” wrote the ATLAS team.
Charting the LandscapeBecause antibodies linger long after diseases have gone, they preserve a molecular record of a person’s immune history. Rather than focusing on a handful of candidates, ATLAS is going fishing: The study will chart the body’s entire antibody repertoire, including autoantibodies, seeking signatures linked to cancer susceptibility or resistance.
The team will first scan blood samples for autoantibodies. They’ll also catalog conventional antibodies, making note of the ones that directly recognize and attack cancers. All this data will go into a comprehensive cancer antibody atlas, giving researchers a resource to explore how different antibodies shape cancer.
To start, the team will study what they call “remarkable groups of people” whose immune systems may hold unusual clues. Among them are healthy centenarians. Although cancer risk usually skyrockets with age as DNA mutations accumulate, these individuals have somehow avoided the disease. Others have remained cancer-free despite smoking, heavy drinking, or carrying cancer-related gene variants such as the BRCA mutations for breast cancer. The team will also study pairs of identical twins where only one sibling developed cancer, allowing them to compare antibody signatures in people with nearly identical genetic blueprints.
Finally, the team plans to track people with cancer before, during, and after immunotherapy, to paint a picture of how immune responses evolve over the course of the treatment.
Ultimately, they expect to find three broad classes of antibodies: those that help or hinder cancers and those that appear largely neutral. Each could prove valuable.
Autoantibodies that blunt anti-cancer immunity could become drug targets. Scientists might make synthetic “decoy” antibodies to block them—in a way, fighting fire with fire. The findings could also inspire next-generation immunotherapies.
On the other hand, autoantibodies that help the immune system recognize cancers could become therapies themselves or complement existing therapies, such as checkpoint inhibitors, which boost the body’s immune response to cancer. These are much less toxic than chemotherapy, but only 20 percent of patients respond, perhaps because of immune differences.
Even seemingly neutral autoantibodies may be useful cancer biomarkers. Because antibody tests are already well-established, fast, and inexpensive, associated neutral antibodies could aid early detection, monitor whether treatments are working, or warn when a cancer is likely to return.
But correlation isn’t causation.
Some antibodies may merely record a person’s immune history rather than actively influencing cancer. To tease the two apart, the team plans to test promising candidates in cultured human cells and mice, to see whether they alter cancer growth or spread. Those experiments could reveal previously hidden molecular communications between the immune system and cancer and deepen our understanding of the deadly disease.
“We should be able to come up with a biomarker to predict who is likely to avoid cancer, [and] who is likely to develop cancer,” said ATLAS team member, Xin Lu at the University of Oxford. “Potentially we could come up with therapeutic, preventative agents [that are] antibody-based. And that would be fantastic.”
The post Why Do Some People Never Get Cancer? The Answer May Be in Their Blood appeared first on SingularityHub.
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